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Article

Genetic alterations in periprosthetic soft-tissue masses from patients with metal-on-metal hip replacement.

Mutation research - 1 Nov 2015

Sarhadi Virinder Kaur, Parkkinen Jyrki, Reito Aleksi, Nieminen Jyrki, Porkka Noora, Wirtanen Tiina, Laitinen Minna, Eskelinen Antti, Knuutila Sakari

Abstract excerpt

Adverse soft tissue reactions in patients with metal-on-metal (MoM) hip replacement are associated with cobalt (Co) and chromium (Cr) particles released from the implant. Exposing the patients to long periods of increased metal ions concentrations resulting from the wear of these implants poses an increased risk of genotoxicity/mutagenicity. A variable proportion of patients develop periprosthetic soft-tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26355908
DOI: 10.1016/j.mrfmmm.2015.08.006

Genes

INSL6
JAK2
NOTCH1
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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