Article
Genetic determinants of cutaneous melanoma predisposition.
Seminars in cutaneous medicine and surgery - 1 Sept 2010
Udayakumar Durga, Mahato Bisundev, Gabree Michele, Tsao Hensin
Abstract excerpt
In the last 2 decades, advances in genomic technologies and molecular biology have accelerated the identification of multiple genetic loci that confer risk for cutaneous melanoma. The risk alleles range from rarely occurring, high-risk variants with a strong familial predisposition to low-risk to moderate-risk variants with modest melanoma association. Although the high-risk alleles are limited to the CDKN2A and...
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