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Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

30 Jul 2014

Abstract excerpt

The RNA-synthesizing machinery of the severe acute respiratory syndrome Coronavirus (SARS-CoV) is composed of 16 non-structural proteins (nsp1-16) encoded by ORF1a/1b. The 148-amino acid nsp10 subunit contains two zinc fingers and is known to interact with both nsp14 and nsp16, stimulating their respective 3'-5' exoribonuclease and 2'-O-methyltransferase activities. Using alanine-scanning mutagenesis, in cellulo...

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PMID: 25074927
DOI: 10.1074/jbc.m114.577353

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