Article
Phenome-wide association studies (PheWASs) for functional variants.
European journal of human genetics : EJHG - 1 Apr 2015
Ye Zhan, Mayer John, Ivacic Lynn, Zhou Zhiyi, He Min, Schrodi Steven J, Page David, Brilliant Murray H, Hebbring Scott J
Abstract excerpt
The genome-wide association study (GWAS) is a powerful approach for studying the genetic complexities of human disease. Unfortunately, GWASs often fail to identify clinically significant associations and describing function can be a challenge. GWAS is a phenotype-to-genotype approach. It is now possible to conduct a converse genotype-to-phenotype approach using extensive electronic medical records to define a...
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