Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites.

doi:10.4269/ajtmh.14-0119

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Article

Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites.

The American journal of tropical medicine and hygiene - 1 Sept 2014

Shekalaghe Seif, Rutaihwa Mastidia, Billingsley Peter F, Chemba Mwajuma, Daubenberger Claudia A, James Eric R, Mpina Maximillian, Ali Juma Omar, Schindler Tobias, Huber Eric, Gunasekera Anusha, Manoj Anita, Simon Beatus, Saverino Elizabeth, Church L W Preston, Hermsen Cornelus C, Sauerwein Robert W, Plowe Christopher, Venkatesan Meera, Sasi Philip, Lweno Omar, Mutani Paul, Hamad Ali, Mohammed Ali, Urassa Alwisa, Mzee Tutu, Padilla Debbie, Ruben Adam, Sim B Kim Lee, Tanner Marcel, Abdulla Salim, Hoffman Stephen L

Abstract excerpt

Controlled human malaria infection (CHMI) by mosquito bite has been used to assess anti-malaria interventions in > 1,500 volunteers since development of methods for infecting mosquitoes by feeding on Plasmodium falciparum (Pf) gametocyte cultures. Such CHMIs have never been used in Africa. Aseptic, purified, cryopreserved Pf sporozoites, PfSPZ Challenge, were used to infect Dutch volunteers by intradermal...

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PMID: 25070995
DOI: 10.4269/ajtmh.14-0119
PMCID: PMC4155546

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