Article
Anti-Pfs25 human plasma reduces transmission of Plasmodium falciparum isolates that have diverse genetic backgrounds.
Infection and immunity - 1 Jun 2013
Da Dari F, Dixit Saurabh, Sattabonkot Jetsumon, Mu Jianbing, Abate Luc, Ramineni Bhanumati, Ouedraogo Jean Bosco, MacDonald Nicholas J, Fay Michael P, Su Xin-zhuan, Cohuet Anna, Wu Yimin
Abstract excerpt
Pfs25 is a leading candidate for a malaria transmission-blocking vaccine whose potential has been demonstrated in a phase 1 trial with recombinant Pfs25 formulated with Montanide ISA51. Because of limited sequence polymorphism, the anti-Pfs25 antibodies induced by this vaccine are likely to have transmission-blocking or -reducing activity against most, if not all, field isolates. To test this hypothesis, we...
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