Article
A SNP in intron 8 of CD46 causes a novel transcript associated with mastitis in Holsteins.
BMC genomics - 28 Jul 2014
Wang Xiuge, Zhong Jifeng, Gao Yundong, Ju Zhihua, Huang Jinming
Abstract excerpt
BACKGROUND: The membrane protein CD46, a ubiquitous cell surface pathogen receptor, can bind Streptococcus to trigger cell autophagy, which is a critical step in the control of infection. RESULTS: In this study, we found a new splice variant designated CD46 transcript variant (CD46-TV). The splice variant is characterized by the retention of a 48 bp sequence from intron 8 of the bovine CD46 gene, which encodes a...
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