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Article

Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing.

European journal of immunology - 1 Jun 1992

Russell S M, Sparrow R L, McKenzie I F, Purcell D F

Abstract excerpt

CD46 (membrane cofactor protein) is a human cell surface glycoprotein with cofactor activity for factor I-mediated cleavage of complement components C3b and C4b. The CD46 protein from normal lymphocytes resolves on sodium dodecyl sulfate-polyacrylamide gel electrophoresis as two major bands of 66 and 56 kDa. CD46 cDNA encodes four extracellular short consensus repeat domains, a Ser/Thr/Pro (STP)-rich region, a...

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Identifiers

PMID: 1601037
DOI: 10.1002/eji.1830220625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing.PMID 1601037Read ↗

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Membrane Cofactor Protein (MCP or CD46): Newest Member of the Regulators of Complement Activation Gene ClusterSemantic proximity Read ↗

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