Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing.

doi:10.1002/eji.1830220625

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Article

Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing.

European journal of immunology - 1 Jun 1992

Russell S M, Sparrow R L, McKenzie I F, Purcell D F

Abstract excerpt

CD46 (membrane cofactor protein) is a human cell surface glycoprotein with cofactor activity for factor I-mediated cleavage of complement components C3b and C4b. The CD46 protein from normal lymphocytes resolves on sodium dodecyl sulfate-polyacrylamide gel electrophoresis as two major bands of 66 and 56 kDa. CD46 cDNA encodes four extracellular short consensus repeat domains, a Ser/Thr/Pro (STP)-rich region, a...

Topics

Alleles
Amino Acid Sequence
Antigens, CD
Base Sequence
Blotting, Western
Chromosome Mapping
Colonic Neoplasms
Exons
Gene Expression Regulation
Granulocytes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoantigens

Leukemia

Lymphocytes

Male

Membrane Cofactor Protein

Membrane Glycoproteins

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 1601037
DOI: 10.1002/eji.1830220625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1601037-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing.PMID 1601037Read ↗

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