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Zebrafish Larvae as a Predictive Model for the Risk of Chemical-Induced Cholestasis: Phenotypic Evaluation and Nomogram Formation.

Chemical research in toxicology - 16 Dec 2024

Qian Si-Tong, Chen Liang-Min, He Ming-Fang, Li Hui-Jun

Abstract excerpt

Chemical-induced cholestasis (CIC) has become a concern in chemical safety risk assessment in pharmaceutical, food, cosmetic, and industrial manufacturing. Currently, known animal and in vitro liver models are unsuitable as high-throughput screening tools due to their high cost, time-consuming, or poor screening accuracy. Herein, a cohort of chemicals validated as cholestatic hepatotoxic in humans, rodents, and...

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Identifiers

PMID: 39566033
DOI: 10.1021/acs.chemrestox.4c00324

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CIC
NPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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