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Article

Phenotypic and biomarker evaluation of zebrafish larvae as an alternative model to predict mammalian hepatotoxicity.

Journal of applied toxicology : JAT - 1 Sept 2016

Verstraelen Sandra, Peers Bernard, Maho Walid, Hollanders Karen, Remy Sylvie, Berckmans Pascale, Covaci Adrian, Witters Hilda

Abstract excerpt

Zebrafish phenotypic assays have shown promise to assess human hepatotoxicity, though scoring of liver morphology remains subjective and difficult to standardize. Liver toxicity in zebrafish larvae at 5 days was assessed using gene expression as the biomarker approach, complementary to phenotypic analysis and analytical data on compound uptake. This approach aimed to contribute to improved hepatotoxicity...

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PMID: 26946349
DOI: 10.1002/jat.3288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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