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Article

Describing the genetic architecture of epilepsy through heritability analysis.

Brain : a journal of neurology - 1 Oct 2014

Speed Doug, O'Brien Terence J, Palotie Aarno, Shkura Kirill, Marson Anthony G, Balding David J, Johnson Michael R

Abstract excerpt

Epilepsy is a disease with substantial missing heritability; despite its high genetic component, genetic association studies have had limited success detecting common variants which influence susceptibility. In this paper, we reassess the role of common variants on epilepsy using extensions of heritability analysis. Our data set consists of 1258 UK patients with epilepsy, of which 958 have focal epilepsy, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25063994
DOI: 10.1093/brain/awu206
PMCID: PMC4163034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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