Article
Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment.
Journal of the National Cancer Institute - 1 Aug 2014
Sadow Peter M, Priolo Carmen, Nanni Simona, Karreth Florian A, Duquette Mark, Martinelli Roberta, Husain Amjad, Clohessy John, Kutzner Heinz, Mentzel Thomas, Carman Christopher V, Farsetti Antonella, Henske Elizabeth Petri, Palescandolo Emanuele, Macconaill Laura E, Chung Seum, Fadda Guido, Lombardi Celestino Pio, De Angelis Antonina M, Durante Oreste, Parker John A, Pontecorvi Alfredo, Dvorak Harold F, Fletcher Christopher, Pandolfi Pier Paolo, Lawler Jack, Nucera Carmelo
Abstract excerpt
Myopericytoma (MPC) is a rare tumor with perivascular proliferation of pluripotent stem-cell-like pericytes. Although indolent, MPC may be locally aggressive with recurrent disease. The pathogenesis and diagnostic biomarkers of MPC are poorly understood. We discovered that 15% of benign MPCs (thyroid, skin; 3 of 20 samples) harbored BRAF(WT/V600E); 33.3% (1 of 3 samples) of BRAF(WT/V600E)-MPCs were...
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