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Article

Distinctive Desmoplastic 3D Morphology Associated With BRAFV600E in Papillary Thyroid Cancers.

The Journal of clinical endocrinology and metabolism - 1 Mar 2018

Tarabichi Maxime, Antoniou Aline, Le Pennec Soazig, Gacquer David, de Saint Aubain Nicolas, Craciun Ligia, Cielen Thierry, Laios Ioanna, Larsimont Denis, Andry Guy, Dumont Jacques Emile, Maenhaut Carine, Detours Vincent

Abstract excerpt

Context: Although 60% of papillary thyroid carcinomas are BRAFV600E mutant (PTCV600E), the increased aggressiveness of these cancers is still debated. Objective: For PTCV600E we aimed to further characterize the extent of the stroma and its activation, the three-dimensional (3D) tumor-stroma interface, and the proliferation rates of tumor and stromal fibroblasts. Design: We analyzed exomes, transcriptomes, and...

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Share to Carcinoma, Papillary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, G-Protein-Coupled

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Source

Identifiers

PMID: 29342254
DOI: 10.1210/jc.2017-02279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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