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Article

SMAD4 suppresses AURKA-induced metastatic phenotypes via degradation of AURKA in a TGFβ-independent manner.

Molecular cancer research : MCR - 1 Dec 2014

Jia Lina, Lee Hun Seok, Wu Chun Fu, Kundu Juthika, Park Sang Gyu, Kim Ryong Nam, Wang Li-Hui, Erkin Özgür Cem, Choi Jong-Sun, Chae Seoung Wan, Yang Ho Bin, Choi Yoon-La, Shin Young Kee

Abstract excerpt

UNLABELLED: SMAD4 has been suggested to inhibit the activity of the WNT/β-catenin signaling pathway in cancer. However, the mechanism by which SMAD4 antagonizes WNT/β-catenin signaling in cancer remains largely unknown. Aurora A kinase (AURKA), which is frequently overexpressed in cancer, increases the transcriptional activity of β-catenin/T-cell factor (TCF) complex by stabilizing β-catenin through the...

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Source

Identifiers

PMID: 25061104
DOI: 10.1158/1541-7786.MCR-14-0191

Genes

AURKA
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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