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Article

AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers

3 Jun 2014

Abstract excerpt

Aurora kinase A is a frequently amplified and overexpressed gene in upper gastrointestinal adenocarcinomas (UGCs). Using in vitro cell models of UGCs, we investigated whether AURKA can regulate Signal Transducer and Activator of Transcription 3 (STAT3). Our data indicate that overexpression of AURKA in FLO-1 and AGS cells increase STAT3 phosphorylation at the Tyr705 site, whereas AURKA genetic depletion by siRNA...

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PMID: 24953013
DOI: 10.1016/j.molonc.2014.05.012

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