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Article

Sro7 and Sro77, the yeast homologues of the Drosophila lethal giant larvae (Lgl), regulate cell proliferation via the Rho1-Tor1 pathway.

Microbiology (Reading, England) - 1 Oct 2014

Liou Liang-Chun, Ren Qun, Gao Qiuqiang, Zhang Zhaojie

Abstract excerpt

Saccharomyces cerevisiae Sro7 and Sro77 are homologues of the Drosophila tumour suppressor lethal giant larvae (Lgl), which regulates cell polarity in Drosophila epithelial cells. Here, we showed that double mutation of SRO7/SRO77 was defective in colony growth. The colony of the SRO7/SRO77 double deletion was much smaller than the WT and appeared to be round with a smooth surface, compared with the WT. Analysis...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Fungal

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Share to Phosphatidylinositol 3-Kinases

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Share to rho GTP-Binding Proteins

Source

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Identifiers

PMID: 25061043
DOI: 10.1099/mic.0.080234-0
PMCID: PMC4178327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sro7 and Sro77, the yeast homologues of the Drosophila lethal giant larvae (Lgl), regulate cell proliferation via the Rho1-Tor1 pathway.PMID 25061043Read ↗

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Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9.Semantic proximity Read ↗

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Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis.Semantic proximity Read ↗

The tumor suppressor gene, lethal(2)giant larvae (1(2)g1), is required for cell shape change of epithelial cells during Drosophila development.Semantic proximity Read ↗

The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast.Semantic proximity Read ↗

Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stress.Semantic proximity Read ↗

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The Saccharomyces cerevisiae SOP1 and SOP2 genes, which act in cation homeostasis, can be functionally substituted by the Drosophila lethal(2)giant larvae tumor suppressor gene.Semantic proximity Read ↗

Small GTPase Rho5 is a functional homologue of Rho1, which controls cell shape and septation in fission yeast.Semantic proximity Read ↗

The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast.Semantic proximity Read ↗

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