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Article

Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis.

Molecular biology of the cell - 15 Mar 2011

Rossi Guendalina, Brennwald Patrick

Abstract excerpt

Lgl family members play an important role in the regulation of cell polarity in eukaryotic cells. The yeast homologues Sro7 and Sro77 are thought to act downstream of the Rab GTPase Sec4 to promote soluble N-ethylmaleimide-sensitive factor adaptor protein receptor (SNARE) function in post-Golgi transport. In this article, we characterize the interaction between Sro7 and the type V myosin Myo2 and show that this...

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Identifiers

PMID: 21248204
DOI: 10.1091/mbc.E10-07-0570
PMCID: PMC3057708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis.PMID 21248204Read ↗

Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis.Semantic proximity Read ↗

Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function.Semantic proximity Read ↗

Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9.Semantic proximity Read ↗

In vitro reconstitution of Rab GTPase-dependent vesicle clustering by the yeast lethal giant larvae/tomosyn homolog, Sro7.Semantic proximity Read ↗

Sro7p, a Saccharomyces cerevisiae counterpart of the tumor suppressor l(2)gl protein, is related to myosins in function.Semantic proximity Read ↗

The tomosyn homologue, Sro7, is a direct effector of the Rab GTPase, Sec4, in post-Golgi vesicle tethering.Semantic proximity Read ↗

Kinesin-related Smy1 enhances the Rab-dependent association of myosin-V with secretory cargo.Semantic proximity Read ↗

The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.Semantic proximity Read ↗

The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting.Semantic proximity Read ↗

An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components.Semantic proximity Read ↗

Sro7 and Sro77, the yeast homologues of the Drosophila lethal giant larvae (Lgl), regulate cell proliferation via the Rho1-Tor1 pathway.Semantic proximity Read ↗

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