Article
The Saccharomyces cerevisiae SOP1 and SOP2 genes, which act in cation homeostasis, can be functionally substituted by the Drosophila lethal(2)giant larvae tumor suppressor gene.
The Journal of biological chemistry - 11 Dec 1998
Larsson K, Böhl F, Sjöström I, Akhtar N, Strand D, Mechler B M, Grabowski R, Adler L
Abstract excerpt
By complementation of a salt-sensitive mutant of Saccharomyces cerevisiae, we cloned the SOP1 gene, encoding a 114.5-kDa protein of 1033 amino acids. Cells deleted for SOP1 exhibited sensitivity to sodium stress, but showed no sensitivity to general osmotic stress. Following exposure of sop1Delta...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- Base Sequence
- Carrier Proteins
- Cytoplasm
- DNA Primers
- Drosophila
- Gene Expression Regulation, Fungal
- Genes, Tumor Suppressor
- Genetic Complementation Test
- Homeostasis
- Humans