Premature aging induced by radiation exhibits pro‐atherosclerotic effects mediated by epigenetic activation of <scp>CD</scp>44 expression

Abstract excerpt

Age is undoubtedly a major risk factor for heart disease. However, the reason for this is not entirely clear. In the course of our investigation into the mechanism of radiation-induced cardiovascular disease, we made several unexpected findings that inform us on this question. We observed that human coronary endothelial cells, while being able to initiate repair of radiation-induced DNA damage, often fail to...

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