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Article

Characterization of DNA damage-induced cellular senescence by ionizing radiation in endothelial cells

29 Oct 2013

Abstract excerpt

PURPOSE: Inhibition of growth in mammalian cells in response to damage or stress is known as cellular senescence. Increasing evidence suggests that double-strand breaks (DSB) commonly mediate cellular senescence. Recently, radiation exposure has been reported to induce premature senescence. MATERIALS AND METHODS: We investigated whether ionizing radiation (IR) at 4 Gy induces cellular senescence with DNA damage...

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PMID: 24164458
DOI: 10.3109/09553002.2014.859763

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