Article
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.
Journal of medical genetics - 1 Sept 2014
Ramos Yolande F M, Metrustry Sarah, Arden Nigel, Bay-Jensen Anne C, Beekman Marian, de Craen Anton J M, Cupples L Adrienne, Esko Tõnu, Evangelou Evangelos, Felson David T, Hart Deborah J, Ioannidis John P A, Karsdal Morten, Kloppenburg Margreet, Lafeber Floris, Metspalu Andres, Panoutsopoulou Kalliope, Slagboom P Eline, Spector Tim D, van Spil Erwin W E, Uitterlinden Andre G, Zhu Yanyan, Valdes Ana M, van Meurs Joyce B J, Meulenbelt Ingrid
Abstract excerpt
BACKGROUND: Research for the use of biomarkers in osteoarthritis (OA) is promising, however, adequate discrimination between patients and controls may be hampered due to innate differences. We set out to identify loci influencing levels of serum cartilage oligomeric protein (sCOMP) and urinary C-telopeptide of type II collagen (uCTX-II). METHODS: Meta-analysis of genome-wide association studies was applied to...
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