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Article

Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family.

Arthritis and rheumatism - 1 Mar 2010

Chen Hsiang-Cheng, Kraus Virginia Byers, Li Yi-Ju, Nelson Sarah, Haynes Carol, Johnson Jessica, Stabler Thomas, Hauser Elizabeth R, Gregory Simon G, Kraus William E, Shah Svati H

Abstract excerpt

OBJECTIVE: The genetic contributions to the multifactorial disorder osteoarthritis (OA) have been increasingly recognized. The goal of the current study was to use OA-related biomarkers of severity and disease burden as quantitative traits to identify genetic susceptibility loci for OA. METHODS: In a large multigenerational extended family (n = 350), we measured 5 OA-related biomarkers: hyaluronan (HA), cartilage...

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PMID: 20187133
DOI: 10.1002/art.27288
PMCID: PMC3684272

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COMP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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