Article
NeEMO: a method using residue interaction networks to improve prediction of protein stability upon mutation.
BMC genomics - 1 Jan 2014
Giollo Manuel, Martin Alberto J M, Walsh Ian, Ferrari Carlo, Tosatto Silvio C E
Abstract excerpt
BACKGROUND: The rapid growth of un-annotated missense variants poses challenges requiring novel strategies for their interpretation. From the thermodynamic point of view, amino acid changes can lead to a change in the internal energy of a protein and induce structural rearrangements. This is of great relevance for the study of diseases and protein design, justifying the development of prediction methods for...
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