Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Brazilian founder mutation TP53 p.R337H is uncommon in Portuguese women diagnosed with breast cancer.

The breast journal - 1 Jan 2000

Giacomazzi Juliana, Correia Rudinei Luis, Palmero Edenir Ines, Gaspar Jorge Francisco, Almeida Marta, Portela Catarina, Camey Suzi Alves, Monteiro Augusta, Pinheiro Manuela, Peixoto Ana, Teixeira Manuel R, Reis Rui Manuel, Ashton-Prolla Patricia

Abstract excerpt

Since the first studies reporting the TP53 p.R337H mutation as founder mutation in Southern and Southeastern Brazil, there has been controversy on its origin. Preliminary analysis of a small subset of Brazilian mutation carriers revealed that the haplotype incided on a Caucasian background. The vast majority of carriers identified today reside in Brazil or, if identified in other countries, are Brazilian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Li-Fraumeni Syndrome

Share to Mutation

Share to Portugal

Share to Tumor Suppressor Protein p53

Share to White People

Source

Identifiers

PMID: 25052705
DOI: 10.1111/tbj.12308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Brazilian founder mutation TP53 p.R337H is uncommon in Portuguese women diagnosed with breast cancer.PMID 25052705Read ↗

Prevalence of the TP53 p.R337H Mutation in Breast Cancer Patients in BrazilSemantic proximity Read ↗

TP53 p.R337H Germline Variant among Women at Risk of Hereditary Breast Cancer in a Public Health System of Midwest Brazil.Semantic proximity Read ↗

A TP53 founder mutation, p.R337H, is associated with phyllodes breast tumors in BrazilSemantic proximity Read ↗

The breast cancer immunophenotype of TP53-p.R337H carriers is different from that observed among other pathogenic TP53 mutation carriers.Semantic proximity Read ↗

The R337H mutation in TP53 and breast cancer in BrazilSemantic proximity Read ↗

Detection of R337H, a germline TP53 mutation predisposing to multiple cancers, in asymptomatic women participating in a breast cancer screening program in Southern Brazil.Semantic proximity Read ↗

Detailed haplotype analysis at the TP53 locus in p.R337H mutation carriers in the population of Southern Brazil: evidence for a founder effect.Semantic proximity Read ↗

Founder effect of the BRCA1 5382insC mutation in Brazilian patients with hereditary breast ovary cancer syndrome.Semantic proximity Read ↗

TP53 p.R337H prevalence in a series of Brazilian hereditary breast cancer familiesSemantic proximity Read ↗

TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics.Semantic proximity Read ↗

Association of the germline TP53 R337H mutation with breast cancer in southern Brazil.Semantic proximity Read ↗

Frequency of the TP53 R337H variant in sporadic breast cancer and its impact on genomic instabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.