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Article

Prevalence of the TP53 p.R337H Mutation in Breast Cancer Patients in Brazil

17 Jun 2014

Abstract excerpt

Germline TP53 mutations predispose individuals to multiple cancers and are associated with Li-Fraumeni/Li-Fraumeni-Like Syndromes (LFS/LFL). The founder mutation TP53 p.R337H is detected in 0.3% of the general population in southern Brazil. This mutation is associated with an increased risk of childhood adrenal cortical carcinoma (ACC) but is also common in Brazilian LFS/LFL families. Breast Cancer (BC) is one of...

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PMID: 24936644
DOI: 10.1371/journal.pone.0099893

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