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Frequency of the TP53 R337H variant in sporadic breast cancer and its impact on genomic instability

6 Oct 2020

Abstract excerpt

The R337H is a TP53 germline pathogenic variant that has been associated with several types of cancers, including breast cancer. Our main objective was to determine the frequency of the R337H variant in sporadic breast cancer patients from Paraná state, South Brazil, its association with prognosis and its impact in genomic instability. The genotyping of 805 breast cancer tissues revealed a genotypic and allelic...

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PMID: 33024147
DOI: 10.1038/s41598-020-73282-y

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