Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes.

Journal of cell science - 15 Nov 2013

Burgoyne Thomas, Jolly Rushee, Martin-Martin Belen, Seabra Miguel C, Piccirillo Rosanna, Schiaffino Maria Vittoria, Futter Clare E

Abstract excerpt

Multivesicular endosomes/bodies (MVBs) deliver proteins, such as activated EGF receptor (EGFR), to the lysosome for degradation, and, in pigmented cells, MVBs containing PMEL are an initial stage in melanosome biogenesis. The mechanisms regulating numbers and fate of different populations of MVB...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endosomes
Share to ErbB Receptors
Share to Eye Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gp100 Melanoma Antigen

Share to HeLa Cells

Share to Lysosomes

Share to Melanosomes

Share to Membrane Glycoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24006264
DOI: 10.1242/jcs.128561
PMCID: PMC3828590

Genes

PMEL
EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24006264-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes.PMID 24006264Read ↗

The ocular albinism type 1 (OA1) protein and the evidence for an intracellular signal transduction system involved in melanosome biogenesis.Semantic proximity Read ↗

Ocular albinism type 1: more than meets the eye.Semantic proximity Read ↗

Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis.Semantic proximity Read ↗

Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation.Semantic proximity Read ↗

Specialised features of melanosomes in health and disease in the retinal pigment epitheliumSemantic proximity Read ↗

Ocular albinism: evidence for a defect in an intracellular signal transduction system.Semantic proximity Read ↗

Spontaneous mutant in threespine stickleback connects endosome trafficking disorders and inflammatory bowel diseases via changes in the gut microbiomeSemantic proximity Read ↗

Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and ProcessingSemantic proximity Read ↗

Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retinaSemantic proximity Read ↗

Linking albinism and immunity: the secrets of secretory lysosomes.Semantic proximity Read ↗

Amelioration of both functional and morphological abnormalities in the retina of a mouse model of ocular albinism following AAV-mediated gene transfer.Semantic proximity Read ↗

<scp>PMEL</scp>: a pigment cell‐specific model for functional amyloid formationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.