Article
Embryonic AP1 Transcription Factor Deficiency Causes a Collodion Baby-Like Phenotype.
The Journal of investigative dermatology - 1 Sept 2017
Young Christina A, Eckert Richard L, Adhikary Gautam, Crumrine Debra, Elias Peter M, Blumenberg Miroslav, Rorke Ellen A
Abstract excerpt
AP1 transcription factors are important controllers of gene expression in the epidermis, and altered AP1 factor function can perturb keratinocyte proliferation and differentiation. However, our understanding of how AP1 signaling changes may underlie or exacerbate skin disease is limited. We have shown that inhibiting AP1 factor function in suprabasal adult epidermis leads to reduced filaggrin levels and to a...
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