Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice.

Nature genetics - 1 Jun 2003

Vrontou Sophia, Petrou Petros, Meyer Barbara I, Galanopoulos Vassilis K, Imai Kenji, Yanagi Masayuki, Chowdhury Kamal, Scambler Peter J, Chalepakis Georges

Abstract excerpt

Loss of tight association between epidermis and dermis underlies several blistering disorders and is frequently caused by impaired function of extracellular matrix (ECM) proteins. Here we describe a new protein in mouse, Fras1, that is specifically detected in a linear fashion underlying the epidermis and the basal surface of other epithelia in embryos. Loss of Fras1 function results in the formation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blister
Share to Extracellular Matrix Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Abnormalities

Share to Gene Targeting

Share to Kidney

Share to Mice, Knockout

Share to Molecular Sequence Data

Source

Identifiers

PMID: 12766770
DOI: 10.1038/ng1168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice.PMID 12766770Read ↗

Generation of mice with a conditional null Fraser syndrome 1 (Fras1) allele.Semantic proximity Read ↗

Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli.Semantic proximity Read ↗

The Fras1/Frem family of extracellular matrix proteins: structure, function, and association with Fraser syndrome and the mouse bleb phenotype.Semantic proximity Read ↗

The genetics of Fraser syndrome and the blebs mouse mutantsSemantic proximity Read ↗

Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein.Semantic proximity Read ↗

The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.Semantic proximity Read ↗

The role of Fras1/Frem proteins in the structure and function of basement membrane.Semantic proximity Read ↗

Basement membrane distortions impair lung lobation and capillary organization in the mouse model for fraser syndrome.Semantic proximity Read ↗

<i>Frem2</i> Knockout Mice Exhibit Fraser Syndrome Phenotypes and Neonatal Lethality Due to Bilateral Renal AgenesisSemantic proximity Read ↗

Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.Semantic proximity Read ↗

Let's stick together: The role of the Fras1 and Frem proteins in epidermal adhesionSemantic proximity Read ↗

bfb, a novel ENU-induced blebs mutant resulting from a missense mutation in Fras1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.