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Article

CCR4 is a determinant of melanoma brain metastasis.

Oncotarget - 9 May 2017

Klein Anat, Sagi-Assif Orit, Meshel Tsipi, Telerman Alona, Izraely Sivan, Ben-Menachem Shlomit, Bayry Jagadeesh, Marzese Diego M, Ohe Shuichi, Hoon Dave S B, Erez Neta, Witz Isaac P

Abstract excerpt

We previously identified the chemokine receptor CCR4 as part of the molecular signature of melanoma brain metastasis. The aim of this study was to determine the functional significance of CCR4 in melanoma brain metastasis. We show that CCR4 is more highly expressed by brain metastasizing melanoma cells than by local cutaneous cells from the same melanoma. Moreover, we found that the expression of CCR4 is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28415693
DOI: 10.18632/oncotarget.16076
PMCID: PMC5458190

Genes

CCR4
CCL17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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