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Article

A global microRNA screen identifies regulators of the ErbB receptor signaling network

28 Jan 2015

Abstract excerpt

BACKGROUND: The growth factor heregulin (HRG) potently stimulates epithelial cell survival and proliferation through the binding of its cognate receptor ErbB3 (also known as HER3). ErbB3-dependent signal transmission relies on the dimerization partner ErbB2, a receptor tyrosine kinase that is frequently overexpressed and/or amplified in breast cancer cells. Substantial evidence suggests that deregulated ErbB3...

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PMID: 25630670
DOI: 10.1186/s12964-015-0084-z

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