Article
Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk.
International journal of cancer - 1 Mar 2015
Nimptsch Katharina, Aleksandrova Krasimira, Boeing Heiner, Janke Jürgen, Lee Young-Ae, Jenab Mazda, Bueno-de-Mesquita H Bas, Jansen Eugène H J M, Tsilidis Konstantinos K, Trichopoulou Antonia, Weiderpass Elisabete, Wu Chunsen, Overvad Kim, Tjønneland Anne, Boutron-Ruault Marie-Christine, Dossus Laure, Racine Antoine, Kaaks Rudolf, Canzian Federico, Lagiou Pagona, Trichopoulos Dimitrios, Palli Domenico, Agnoli Claudia, Tumino Rosario, Vineis Paolo, Panico Salvatore, Johansson Anders, Van Guelpen Bethany, Khaw Kay-Tee, Wareham Nick, Peeters Petra H, Quirós J Ramón, Venceslá García Adoración, Molina-Montes Esther, Dorronsoro Miren, Chirlaque María-Dolores, Barricarte Gurrea Aurelio, Key Timothy J, Duarte-Salles Talita, Stepien Magdalena, Gunter Marc J, Riboli Elio, Pischon Tobias
Abstract excerpt
High blood concentrations of C-reactive protein (CRP) have been associated with elevated risk of colorectal cancer in several prospective studies including the European Prospective Investigation into Cancer and Nutrition (EPIC), but it is unknown whether these observations reflect a causal relationship. We aimed to investigate whether CRP genetic variants associated with lifelong higher CRP concentrations...
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