Article
Multiple gene polymorphisms can improve prediction of nonvertebral fracture in postmenopausal women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2013
Lee Seung Hun, Lee Seon Woo, Ahn Seong Hee, Kim Taehyeung, Lim Kyeong-Hye, Kim Beom-Jun, Cho Eun-Hee, Kim Sang-Wook, Kim Tae-Ho, Kim Ghi Su, Kim Shin-Yoon, Koh Jung-Min, Kang Changwon
Abstract excerpt
Clinical risk factors (CRFs), with or without bone mineral density (BMD), are used to determine the risk of osteoporotic fracture (OF), which has a heritable component. In this study we investigated whether genetic profiling can additionally improve the ability to predict OF. Using 1229 unrelated Korean postmenopausal women, 39 single-nucleotide polymorphisms (SNPs) in 30 human genomic loci were tested for...
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