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Article

Up‐regulation of the interferon‐related genes in BRCA2 knockout epithelial cells

11 Jul 2014

Abstract excerpt

BRCA2 mutations are significantly associated with early-onset breast cancer, and the tumour-suppressing function of BRCA2 has been attributed to its involvement in homologous recombination (HR)-mediated DNA repair. In order to identify additional functions of BRCA2, we generated BRCA2-knockout HCT116 human colorectal carcinoma cells. Using genome-wide microarray analyses, we have discovered a link between the...

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PMID: 25043256
DOI: 10.1002/path.4404

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