Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-6388 regulates granulosa cell function in sheep by targeting GDF9 and modulating the TGF-β signaling pathway.

Theriogenology - 1 Dec 2026

Xu Jianyu, Bai Yanyu, An Xinyue, Alatan Suhe, Gan Zhuer, Naren Zhana, Bu He, Cao Guifang, Cang Ming, Tong Bin

Abstract excerpt

Litter size is an economically important trait in sheep and is closely associated with ovarian follicular development and granulosa cell (GC) function. This study investigated the association between GDF9 polymorphisms and litter size, and examined the post-transcriptional regulation of GDF9 by miR-6388 in ovine GCs. Variants were initially identified by Sanger sequencing in 20 ewes, and subsequently genotyped in...

Read the complete abstract on PubMed

Topics

Animals
Female
MicroRNAs
Growth Differentiation Factor 9
Granulosa Cells
Signal Transduction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Sheep

Gene Expression Regulation

Transforming Growth Factor beta

Litter Size

Polymorphism, Single Nucleotide

3' Untranslated Regions

Source

Identifiers

PMID: 42641285
DOI: 10.1016/j.theriogenology.2026.118154

Genes

GDF9
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-6388 regulates granulosa cell function in sheep by targeting GDF9 and modulating the TGF-β signaling pathway.PMID 42641285Read ↗

Three Complete Linkage SNPs of GDF9 Gene Affect the Litter Size Probably Mediated by OCT1 in Hu Sheep.Semantic proximity Read ↗

miR-133 could affect proliferation and apoptosis of ovine granulosa cells by regulating the expression of B4GALNT2.Semantic proximity Read ↗

Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Size in Mongolia Sheep.Semantic proximity Read ↗

Identification of a mutation in GDF9 as a novel cause of diminished ovarian reserve in young women.Semantic proximity Read ↗

Integral role of GDF-9 and BMP-15 in ovarian function.Semantic proximity Read ↗

Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility in Thoka sheep.Semantic proximity Read ↗

Association of BMP15 and GDF9 Gene Polymorphisms with Litter Size in Hu SheepSemantic proximity Read ↗

Polymorphisms of caprine GDF9 gene and their association with litter size in Jining Grey goats.Semantic proximity Read ↗

miR-1306 induces cell apoptosis by targeting BMPR1B gene in the ovine granulosa cellsSemantic proximity Read ↗

Genetic Variation of Chicken Growth Differentiation Factor-9 Gene and Association With Egg Characteristics: A Systematic Review.Semantic proximity Read ↗

miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9Semantic proximity Read ↗

GDF9His209GlnfsTer6/S428T and GDF9Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargementSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.