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Article

A common hypofunctional genetic variant of GPER is associated with increased blood pressure in women.

British journal of clinical pharmacology - 1 Dec 2014

Feldman Ross D, Gros Robert, Ding Qingming, Hussain Yasin, Ban Matthew R, McIntyre Adam D, Hegele Robert A

Abstract excerpt

AIMS: Activation of vascular GPER has been linked to vasodepressor effects in animals. However, the significance of GPER regulation on chronic blood pressure control in humans is unknown. METHODS: To examine this question we determined the functional significance of expression of a common missense single nucleotide variant of GPER, P16L in vascular smooth muscle cells, and its association with blood pressure in...

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Identifiers

PMID: 25039431
DOI: 10.1111/bcp.12471
PMCID: PMC4256633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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