β2 -adrenergic receptor Thr164IIe polymorphism, blood pressure and ischaemic heart disease in 66 750 individuals.

doi:10.1111/j.1365-2796.2011.02447.x

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Article

β2 -adrenergic receptor Thr164IIe polymorphism, blood pressure and ischaemic heart disease in 66 750 individuals.

Journal of internal medicine - 1 Mar 2012

Thomsen M, Dahl M, Tybjaerg-Hansen A, Nordestgaard B G

Abstract excerpt

OBJECTIVES: The β(2) -adrenergic receptor (ADRB2) is located on smooth muscle cells and is an important regulator of smooth muscle tone. The Thr164Ile polymorphism (rs1800888) in the ADRB2 gene is rare but has profound functional consequences on receptor function and could cause lifelong elevated smooth muscle tone. We tested the hypothesis that Thr164Ile is associated with increased blood pressure, increased...

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PMID: 21883537
DOI: 10.1111/j.1365-2796.2011.02447.x

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ADRB2

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