Article
Parallel universes of Black Six biology.
Biology direct - 19 Jul 2014
Kraev Alexander
Abstract excerpt
UNLABELLED: Creation of lethal and synthetic lethal mutations in an experimental organism is a cornerstone of genetic dissection of gene function, and is related to the concept of an essential gene. Common inbred mouse strains carry background mutations, which can act as genetic modifiers, interfering with the assignment of gene essentiality. The inbred strain C57BL/6J, commonly known as "Black Six", stands out,...
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