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Article

Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew.

Nature biotechnology - 1 Sept 2014

Wang Yanpeng, Cheng Xi, Shan Qiwei, Zhang Yi, Liu Jinxing, Gao Caixia, Qiu Jin-Long

Abstract excerpt

Sequence-specific nucleases have been applied to engineer targeted modifications in polyploid genomes, but simultaneous modification of multiple homoeoalleles has not been reported. Here we use transcription activator-like effector nuclease (TALEN) and clustered, regularly interspaced, short palindromic repeats (CRISPR)-Cas9 (refs. 4,5) technologies in hexaploid bread wheat to introduce targeted mutations in the...

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PMID: 25038773
DOI: 10.1038/nbt.2969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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