Article
Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma.
Human genetics - 1 Oct 2014
Bailey Jessica N Cooke, Yaspan Brian L, Pasquale Louis R, Hauser Michael A, Kang Jae H, Loomis Stephanie J, Brilliant Murray, Budenz Donald L, Christen William G, Fingert John, Gaasterland Douglas, Gaasterland Terry, Kraft Peter, Lee Richard K, Lichter Paul R, Liu Yutao, McCarty Catherine A, Moroi Sayoko E, Richards Julia E, Realini Tony, Schuman Joel S, Scott William K, Singh Kuldev, Sit Arthur J, Vollrath Douglas, Wollstein Gadi, Zack Donald J, Zhang Kang, Pericak-Vance Margaret A, Allingham R Rand, Weinreb Robert N, Haines Jonathan L, Wiggs Janey L
Abstract excerpt
Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. Using genome-wide association single-nucleotide polymorphism data from the Glaucoma Genes and Environment study and National Eye Institute Glaucoma Human Genetics Collaboration comprising 3,108 cases and 3,430 controls, we assessed biologic pathways as annotated in the KEGG database for association with risk of POAG. After correction...
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