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Article

Bioinformatic Prioritization and Functional Annotation of GWAS-Based Candidate Genes for Primary Open-Angle Glaucoma.

Genes - 13 Jun 2022

Asefa Nigus G, Kamali Zoha, Pereira Satyajit, Vaez Ahmad, Jansonius Nomdo, Bergen Arthur A, Snieder Harold

Abstract excerpt

Background: Primary open-angle glaucoma (POAG) is the most prevalent glaucoma subtype, but its exact etiology is still unknown. In this study, we aimed to prioritize the most likely ‘causal’ genes and identify functional characteristics and underlying biological pathways of POAG candidate genes. Methods: We used the results of a large POAG genome-wide association analysis study from GERA and UK Biobank cohorts....

Topics

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Computational Biology
Genome-Wide Association Study
Glaucoma and retinal disorders
Glaucoma, Open-Angle
Intraocular Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Retinal Development and Disorders

Ubiquitin and proteasome pathways

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Identifiers

PMID: 35741817
DOI: 10.3390/genes13061055
PMCID: PMC9222386

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