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Article

JCV GCN in a natalizumab-treated MS patient is associated with mutations of the VP1 capsid gene.

Neurology - 19 Aug 2014

Agnihotri Shruti P, Dang Xin, Carter Jonathan L, Fife Terry D, Bord Evelyn, Batson Stephanie, Koralnik Igor J

Abstract excerpt

OBJECTIVE: To describe the clinical, neuroimaging, immunologic, and virologic characteristics of JC virus-associated granule cell neuronopathy (JCV GCN) in a natalizumab-treated patient with multiple sclerosis (MS) who developed immune reconstitution inflammatory syndrome (IRIS) after natalizumab withdrawal. METHODS: We obtained longitudinal clinical data as well as MRI and proton magnetic resonance spectroscopy...

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukoencephalopathy, Progressive Multifocal

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Source

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Identifiers

PMID: 25037207
DOI: 10.1212/WNL.0000000000000713
PMCID: PMC4150135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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