Article
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters.
Cell - 17 Jul 2014
Cimermancic Peter, Medema Marnix H, Claesen Jan, Kurita Kenji, Wieland Brown Laura C, Mavrommatis Konstantinos, Pati Amrita, Godfrey Paul A, Koehrsen Michael, Clardy Jon, Birren Bruce W, Takano Eriko, Sali Andrej, Linington Roger G, Fischbach Michael A
Abstract excerpt
Although biosynthetic gene clusters (BGCs) have been discovered for hundreds of bacterial metabolites, our knowledge of their diversity remains limited. Here, we used a novel algorithm to systematically identify BGCs in the extensive extant microbial sequencing data. Network analysis of the predicted BGCs revealed large gene cluster families, the vast majority uncharacterized. We experimentally characterized the...
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