Article

The biosynthetic gene cluster landscape of the oral microbiome across health and dental caries

2025-09-08

Abstract excerpt

Specialized metabolites encoded by biosynthetic gene clusters (BGCs) in the oral microbiome remain largely unexplored in the context of oral health and disease. Previous genome-centric surveys have cataloged hundreds of uncharacterized BGCs in the oral cavity associated with health and disease, but these studies relied on reference genomes and did not capture strain-level variation or the native distribution of BG...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b7e1c052-cd0e-5cd7-9f42-3d0cd6f8f9ad
DOI: 10.1101/2025.09.04.674288

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The biosynthetic gene cluster landscape of the oral microbiome across health and dental cariesDOI 10.1101/2025.09.04.674288Read

Multi-Site Analysis of Biosynthetic Gene Clusters (BGCs) from the Periodontitis Oral MicrobiomeSemantic proximity Read

Identification of the bacterial biosynthetic gene clusters of the oral microbiome illuminates the unexplored social language of bacteria during health and diseaseSemantic proximity Read

Integrated oral microbiome profiling from aligners, saliva, and plaque identifies biosynthetic signatures of diseaseSemantic proximity Read

Deep metagenomics examines the oral microbiome during dental caries, revealing novel taxa and co-occurrences with host moleculesSemantic proximity Read

BiG-MAP: an automated pipeline to profile metabolic gene cluster abundance and expression in microbiomesSemantic proximity Read

Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutansSemantic proximity Read

Caries-Associated Biosynthetic Gene Clusters in Streptococcus mutansSemantic proximity Read

Comparative Metatranscriptomics of Periodontitis Supports a Common Polymicrobial Shift in Metabolic Function and Identifies Novel Putative Disease-Associated ncRNAsSemantic proximity Read

Comparative metatranscriptomics of periodontitis supports a common polymicrobial shift in metabolic function and identifies novel putative disease-associated ncRNAsSemantic proximity Read

Metabolites of the oral microbiome: important mediators of multikingdom interactionsSemantic proximity Read

Supragingival plaque microbiome ecology and functional potential in the context of health and diseaseSemantic proximity Read

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of AntibioticsSemantic proximity Read