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Staphylococcus epidermidis alters macrophage polarization and phagocytic uptake by extracellular DNA release in vitro

20 Nov 2024

Abstract excerpt

Biofilm formation shields Staphylococcus epidermidis from host defense mechanisms, contributing to chronic implant infections. Using wild-type S. epidermidis 1457, a PIA-negative mutant (1457-M10), and an eDNA-negative mutant (1457ΔatlE), this study examined the influence of biofilm matrix components on human monocyte-derived macrophage (hMDM) interactions. The wild-type strain was resistant to phagocytosis and...

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PMID: 39567551
DOI: 10.1038/s41522-024-00604-7

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