Article
Estimation of the RNU2 macrosatellite mutation rate by BRCA1 mutation tracing.
Nucleic acids research - 1 Aug 2014
Tessereau Chloé, Lesecque Yann, Monnet Nastasia, Buisson Monique, Barjhoux Laure, Léoné Mélanie, Feng Bingjian, Goldgar David E, Sinilnikova Olga M, Mousset Sylvain, Duret Laurent, Mazoyer Sylvie
Abstract excerpt
Large tandem repeat sequences have been poorly investigated as severe technical limitations and their frequent absence from the genome reference hinder their analysis. Extensive allelotyping of this class of variation has not been possible until now and their mutational dynamics are still poorly known. In order to estimate the mutation rate of a macrosatellite, we analysed in detail the RNU2 locus, which displays...
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