Birth and evolutionary history of a human minisatellite.

doi:10.1093/molbev/msh007

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Article

Birth and evolutionary history of a human minisatellite.

Molecular biology and evolution - 1 Feb 2004

Boán Francisco, Blanco Miguel G, Quinteiro Javier, Mouriño Susana, Gómez-Márquez Jaime

Abstract excerpt

One of the most exciting challenges in human biology is the understanding of how our genome was constructed during evolution. Here we explore the evolutionary history of the low polymorphic human minisatellite MsH42 and its flanking sequences. We show that the evolutionary birth of MsH42 took place within an intron, early in primate lineage evolution, more than 40 MYA. Then, single base-pair changes and...

Topics

Animals
Base Sequence
Chromosomes, Human, Pair 15
Evolution, Molecular
Genome, Human
Haplorhini
Humans
Introns
Minisatellite Repeats
Molecular Sequence Data
Mutation
Polymorphism, Genetic
Sequence Homology, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 14595097
DOI: 10.1093/molbev/msh007

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