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Article

Interactive webtool for analyzing drug sensitivity and resistance associated with genetic signatures of cancer cell lines.

Journal of cancer research and clinical oncology - 1 Aug 2023

Boeschen Myriam, Le Duc Diana, Stiller Mathias, von Laffert Maximilian, Schöneberg Torsten, Horn Susanne

Abstract excerpt

PURPOSE: A wide therapeutic repertoire has become available to oncologists including radio- and chemotherapy, small molecules and monoclonal antibodies. However, drug efficacy can be limited by genetic heterogeneity. Here, we designed a webtool that facilitates the data analysis of the in vitro drug sensitivity data on 265 approved compounds from the GDSC database in association with a plethora of genetic changes...

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Source

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Identifiers

PMID: 36472769
DOI: 10.1007/s00432-022-04503-2
PMCID: PMC10356876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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