Article
Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells.
Molecular cancer research : MCR - 1 Oct 2014
Chan Norman, Ali Mohsin, McCallum Gordon P, Kumareswaran Ramya, Koritzinsky Marianne, Wouters Bradly G, Wells Peter G, Gallinger Steven, Bristow Robert G
Abstract excerpt
UNLABELLED: Regions of acute and chronic hypoxia exist within solid tumors and can lead to increased rates of mutagenesis and/or altered DNA damage and repair protein expression. Base excision repair (BER) is responsible for resolving small, non-helix-distorting lesions from the genome that potentially cause mutations by mispairing or promoting DNA breaks during replication. Germline and somatic mutations in BER...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.