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Article

The hypoxic tumor microenvironment in vivo selects tumor cells with increased survival against genotoxic stresses.

Cancer letters - 1 Sept 2018

Kim Hoon, Lin Qun, Yun Zhong

Abstract excerpt

Tumor sensitivity to radiation therapy has been known to be dependent on O2 concentrations. However, radiosensitivity of naturally occurring hypoxic tumor cells remains to be well fully investigated in direct comparison to that of their adjacent non-hypoxic tumor cells within the same tumor. We developed a hypoxia-sensing xenograft model using the hypoxia-response element (HRE)-driven enhanced green fluorescence...

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Identifiers

PMID: 29859297
DOI: 10.1016/j.canlet.2018.05.047
PMCID: PMC6026555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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